Real world data guidelines - current status review

Objective: to identify existing guidelines for real world data collection and analysis. Methods: we performed Pub-Med search in literature for guidelines and recommendations for real world data studies. Results: Based on the performed search we have obtained in total 97661 records. After analysis and selection we finally identified 40 publications fitting our search criteria and we found that only 2 were dedicated to RWD and provided some guidelines to researchers. Conclusion: The published guidelines are usually focused on specific type of RWD studies and there are not many guidelines available in relation to real world data methodology research in general. In view of the potential use of RWD in decision making specific guidelines on how to conduct RWD research are needed.